Profile

Professional career

• since 04/2003
  Scientific position, Institute of Immunology (Veterinary faculty, University of Leipzig)
• 04/2013
  Habilitation in Immunology (Veterinary faculty, University of Leipzig)
• 12/2001 - 03/2003
  Assistance position, Institute of Immunology (Veterinary faculty, University of Leipzig)
• 07/2001 - 11/2001
  Post Doc position, Institute of Immunology (Veterinary faculty, University of Leipzig)
• 06/1998 - 05/2001
  Doctoral thesis in Biology, work group Parasitology (Ruhr University of Bochum) at the Max Planck Institute of Immunobiology, Freiburg

Education

• 06/1997 - 05/1998
  Diploma thesis in Biology, work group Parasitology (Ruhr University of Bochum) at the Max Planck Institute of Immunobiology, Freiburg
• 10/1992 - 05/1997
  Studies of Biology a the Ruhr University of Bochum

In his diploma and doctoral theses Uwe Müller focussed on the infectious immunological question of interactions of the intracellular parasite Trypanosoma cruzi with the host immune system at the Max Planck Institute of Immunobiology. Subsequent he switched his field of interest from parasites to fungal pathogens, therefore he moved to the Institute of Immunology in the Veterinarian Faculty of the University of Leipzig. Under the supervision of Prof. Alber he examined the role of allergy-related cytokines and cytokine receptors in pulmonary cryptococcosis. Concomitant with this work he raised funds from the DFG to answer question to characterize cells involved in immunopathology in pulmonary cryptoccococsis. In a recent project he focussed on the role of lung epithelial cells in cryptococcosis, especially barrier function and modulation of the immune response. For this work he established in vitro models.

Methods:

• PCR, RT-PCR
• SDS-PAGE/Westerblot
• ELISA
• FACS analysis and sorting
• In vitro/vivo models

• Role of early IL-4 in pulmonary cryptococcosis

  Müller, Uwe

  Duration: 05/2011 – 08/2015

  Funded by: DFG Deutsche Forschungsgemeinschaft

  Involved organisational units of Leipzig University: Molekulare Pathogenese; Biotechnologisch-Biomedizinisches Zentrum (BBZ)
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• In vitro system for characterizing the allergic potential of human and animal pathogenic fungi

  Müller, Uwe

  Duration: 09/2019 – 03/2021

  Funded by: BMBF Bundesministerium für Bildung und Forschung

  Involved organisational units of Leipzig University: Immunologie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)
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more projects

• Piehler, D.; Eschke, M.; Schulze-Richter, B.; Protschka, M.; Müller, U.; Grahnert, A.; Richter, T.; Heyen, L.; Köhler, G.; Brombacher, F.; Alber, G.

  The IL-33 receptor (ST2) regulates early IL-13 production in fungus-induced allergic airway inflammation

  Mucosal Immunology. 2016. 9 (4). pp. 937–949.

  DOI: 10.1038/mi.2015.106
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• Müller, U.; Stenzel, W.; Piehler, D.; Grahnert, A.; Protschka, M.; Köhler, G.; Frey, O.; Held, J.; Richter, T.; Eschke, M.; Kamradt, T.; Brombacher, F.; Alber, G.

  The role of macrophages in IL-4 receptor (IL-4R)-dependent pathology in pulmonary cryptococcosis

  MYCOSES. 2015. 58 (S3). pp. 65–66.

  DOI: 10.1111/myc.12362
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• Müller, U.; Stenzel, W.; Piehler, D.; Grahnert, A.; Protschka, M.; Köhler, G.; Frey, O.; Held, J.; Richter, T.; Eschke, M.; Kamradt, T.; Brombacher, F.; Alber, G.

  Abrogation Of Il-4 Receptor-Alpha-Dependent Alternatively Activated Macrophages Is Sufficient To Confer Resistance Against Pulmonary Cryptococcosis Despite An Ongoing T(H)2 Response

  International immunology. 2013. 25 (8). pp. 459–470.

  DOI: 10.1093/intimm/dxt003
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• Müller, U.; Piehler, D.; Stenzel, W.; Köhler, G.; Frey, O.; Held, J.; Grahnert, A.; Richter, T.; Eschke, M.; Kamradt, T.; Brombacher, F.; Alber, G.

  Lack Of Il-4 Receptor Expression On T Helper Cells Reduces T Helper 2 Cell Polyfunctionality And Confers Resistance In Allergic Bronchopulmonary Mycosis

  Mucosal immunology. 2012. 5 (3). pp. 299–310.

  DOI: 10.1038/mi.2012.9
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• Stenzel, W.; Müller, U.; Köhler, G.; Heppner, F. L.; Blessing, M.; McKenzie, A. N. J.; Brombacher, F.; Alber, G.

  Il-4/Il-13-Dependent Alternative Activation Of Macrophages But Not Microglial Cells Is Associated With Uncontrolled Cerebral Cryptococcosis

  The American journal of pathology. 2009. 174 (2). pp. 486–496.

  DOI: 10.2353/ajpath.2009.080598
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more publications

• Molekulare Pathogenese; Medizinische Fakultät und Universitätsklinikum AöR; Biotechnologisch-Biomedizinisches Zentrum (BBZ)

  Pulmologische Untersuchungen während der Kryptokokkose

  Start Date of Collaboration: 01/12/2016

  Involved persons: Müller, Uwe; Polte, Tobias
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• Molekulare Pathogenese; Institut für Parasitologie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)

  Charakterisierung von Kryptosporidienstadien mittels Durchflusszytometrie

  Start Date of Collaboration: 01/01/2016

  Involved persons: Müller, Uwe; Daugschies, Arwid; Lendner, Matthias
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• Molekulare Pathogenese; Medizinische Fakultät und Universitätsklinikum AöR; Institut für Immunologie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)

  Mikroskopische Untersuchungen von Alveolarepithel während der pulmonalen Kryptokokkose

  Start Date of Collaboration: 01/01/2015

  Involved persons: Alber, Gottfried; Gericke, Martin; Heyen, Laura; Piehler, Daniel; Müller, Uwe
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more cooperations

Immunology, laboratory animal science, and genetics are the main topics of Uwe Müller's lectures. Since 2001 Uwe Müller participates in the lectures, required electives, and trainings in immunology and laboratory animal science. In 2014 he resumed the genetics lectures. Together with Prof. Alber and Dr. Eschke Uwe Müller is responsible for the teachings of the Institute of Immunology at the Veterinary faculty.

Recently he is involved in the following courses

Immunology

• Focus Erkennen, Verstehen, Behandeln (5/6th sem.): humoral immunological diagnostics (2h)
• Focus Blut (8th sem.): canine and feline blood types (1h)
• Focus Geflügel (8th sem.): The avian immune system & vaccination strategies (2h)
• Focus Zelle (2nd sem.): cell cycle, from gene to protein (3h)

Laboratory animal science

• Laboratory animal science (5th sem.): laboratory mouse, pig (2-3h)

Animal breeding and genetics

• Genetics (2nd/3rd sem.): (i) classical and molecular genetics, (ii) population genetics and evolution, (iii) pathogenetics (42h)

Exams

Immunology

• written examination (mandatory for all students)

Laboratory animal science

• written examination (optional)

Animal breeding and genetics

• written examination (mandatory for all students), 3. try oral examination

• Zoology (part: evolution, immunology)

  Aspects and forces of evolution will be presented in this lecture in 3 lessons. In 5 lessions immunological aspects, i.a. innate immunity and immune evasion mechanisms will be in focus.

• Animal breeding and Genetics

  In this lecture different aspects of genetic will be in focus, (i) classic and molecular genetics, (ii) population genetics and evolution, and (iii) pathogenetics. In total the lecture comprises 42 lessons in the 2nd and 3rd term.

• Laboratory animals

  Experts in their field present different species of laboratory animals and applications in which they are used. Beside animal models also aspects of ethics and alternative methods will be demonstrated.

• Use of digital tools

  Moodle, Zoom and other digital formats offer a lot of potential to intensify teaching and to provide students with opportunities to repeat teaching content (e.g. via digital online presentations and films), to evaluate learning success (e.g. via online exercises and tests) and also to intensify contact between the teacher and the learner. A variety of tools are used to improve teaching and take it to a new level.